After dropping the champion with a stiff jab, ‘The Predator’ then dropped the 38-year-old with a chopping left hook to finish the fight.
Ngannou was frantic and rushed in the first fight, swinging wildly and wasting valuable energy back in 2018.
However, under the tutelage of Eric Nicksick, the Cameroonian looked composed and dangerous from the very first bell and hurt the champion.
In front of the watching Kourtney Kardashian and Megan Fox, Ngannou landed a huge right hand in the first and then stuffed a takedown – something which was a huge factor in the first fight.
Having landed powerful bombs, Ngannou was then measured in his approach and waited for his opportunity.
It came in the second round, on the back of a series of concussive punches which rendered the greatest heavyweight champion in history out cold.
It means a fight with former UFC light-heavyweight champion Jon Jones is a real possibility, with ‘Bones’ moving up to heavyweight after a successful career at 205lbs.
Taking to Twitter, the 33-year-old wrote: “Show me the money.”
Miocic was hoping to defend the UFC heavyweight title for a record seventh time, but looked unable to work out the new and composed Ngannou in front of him.
With significant damage around his left eye, the Cleveland-native slumped onto his stool after a really difficult first round.
After being dropped in the second round, Miocic tried to return fire with fire and landed a right hand, but it proved to be in vain as Ngannou dropped the champion with a chopping left hook to ensure the belt will go back to Batie in Cameroon.
Francis Ngannou knocks out Stipe Miocic at UFC 260